Genetics and male infertility

Genetics and Male Infertility

Male are the sole cause of infertility in approximately 20% of infertile couples and are an important contributing factor in another 20-40% of couples with reproductive failure. Male infertility can result from a variety of causes. Some, like ductal obstruction and hypogonadotropic hypogonadism, can be accurately defined and effectively treated. Genetic abnormalities can cause infertility by in...

Silber GENETICS OF MALE INFERTILITY

LEARNING OBJECTIVES 1. The ART physician should understand the structure of the Y chromosome, why it harbors genes required for spermatogenesis, and why it so frequently has deletions which result in azoospermia and severe oligospermia. 2. The ART physician should understand the pitfalls in interpreting standard Y deletion testing, and be able to identify those STS markers which are robust and ...

Genetics of human male infertility.

Infertility is defined as a failure to conceive in a couple trying to reproduce for a period of two years without conception. Approximately 15 percent of couples are infertile, and among these couples, male factor infertility accounts for approximately 50 percent of causes. Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In more than half of infertile men...

Male Infertility: Genetics, Mechanism, and Therapies.

ACUPUNCTURE AND MALE INFERTILITY About male infertility

The clinical definition of male infertility is the presence of abnormal semen parameters in the male partner of a couple who have been unable to conceive after 1 year of unprotected intercourse (Dohle 2010). The World Health Organization defines male factor infertility as the presence of one or more abnormalities in the semen analysis, or the presence of inadequate sexual or ejaculatory functio...